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Updated: Jul 8, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Implications of activity-dependent neurotransmitter-receptor matching
Nicholas C Spitzer1, Laura N Borodinsky
1Neurobiology Section, Division of Biological Sciences, Center for Molecular Genetics, Kavli Institute for Brain and Mind, UCSD, La Jolla, CA 92093, USA. nspitzer@ucsd.edu
Abstract:
Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.
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