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Updated: Jun 29, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp
Hui Zhang1, Andrew Skildum, Emily Stromquist
1Department of Chemistry and Biochemistry, University of Minnesota Duluth, 1039 University Drive, Duluth, Minnesota 55812,USA.
Abstract:
A new polybrominated diphenyl ether ( 9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.
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