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Updated: Jul 8, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Psychiatric comorbidity in young cocaine users: induced versus independent disorders
M Jesús Herrero1, Antonia Domingo-Salvany, Marta Torrens
1Health Services Research Unit (IMIM-Hospital del Mar), Barcelona, Spain.
Aims:
To examine the psychiatric status of young cocaine users using a validated instrument for the evaluation of psychiatric comorbidity, emphasizing the distinction between independent and induced psychiatric conditions.
Design:
Cross-sectional study.
Setting:
Barcelona, Spain.
Participants:
A cohort of 139 young (18-30 years) adult current regular cocaine users.
Measurements:
The Psychiatric Research Interview for Substance and Mental Disorders (PRISM-IV, which produces diagnoses according to DSM-IV criteria, including Axis II antisocial and borderline personality disorders).
Findings:
Nearly 42.5% of the subjects presented psychiatric comorbidity. The most common Axis I diagnoses were mood disorders (26.6%) and anxiety disorders (13%). Increasing age, having ever received treatment for drug use and freebase cocaine use were associated with substance-induced disorders diagnoses relative to primary Axis I disorders.
Conclusions:
This study has shown a relatively high prevalence of psychiatric comorbidity in cocaine users recruited in non-clinical settings. Future studies examining potential differential factors associated with primary versus substance-induced disorders are necessary to optimize the implementation of more suitable approaching programmes for young regular cocaine users.
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