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Neurogenesis Using P19 Embryonal Carcinoma Cells
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Neurogenesis Using P19 Embryonal Carcinoma Cells

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Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells

Izuho Hatada1, Sumiyo Morita2, Mika Kimura2

  • 1Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, 371-8512, Japan. ihatada@showa.gunma-u.ac.jp.

Journal of Human Genetics
|January 18, 2008
PubMed

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Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...