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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Nanovehicular intracellular delivery systems.

Ales Prokop¹, Jeffrey M Davidson

¹Department of Chemical Engineering, 24th Avenue & Garland Avenues, 107 Olin Hall, Vanderbilt University, Nashville, Tennessee 37235, USA. ales.prokop@vanderbilt.edu

Journal of Pharmaceutical Sciences

|January 18, 2008

Summary

This article reviews nanovehicles (NV) for intracellular drug and gene delivery, discussing principles, barriers, and targeting strategies. It highlights newer NV technologies and their future applications in medicine.

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Area of Science:

Nanotechnology
Biomedical Engineering
Pharmacology

Background:

Intracellular drug and gene delivery faces challenges in transport, accumulation, and retention.
Nanovehicles (NV) offer a promising approach to overcome these barriers.
Understanding NV behavior is crucial for targeted therapeutic action.

Purpose of the Study:

To provide an overview of principles and barriers in intracellular drug and gene delivery using nanovehicles.
To discuss localization, targeting, and pharmacokinetic/pharmacodynamic aspects of NV.
To highlight recent advancements and future applications of NV technologies.

Main Methods:

Review of existing literature on nanovehicle principles and barriers.
Discussion of localization and targeting strategies for intracellular delivery.
Overview of modeling tools for NV behavior in vascular and tumor compartments.

Main Results:

Nanovehicles are defined as nanosized particles capable of intracellular cargo delivery.
Various localization and targeting methods are discussed, alongside pharmacokinetic and pharmacodynamic considerations.
Newer NV developments and future applications are outlined, contrasting with current nanotechnologies.

Conclusions:

Nanovehicles hold significant potential for targeted intracellular drug and gene delivery.
Multi-scale modeling and systems biology approaches are important for understanding NV behavior.
Further development of NV technologies is crucial for future therapeutic applications.