Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liver-derived Indian hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis.

Molecular metabolism·2026
Same author

Resolving early embryonic metabolism in Drosophila through single-embryo metabolomics and transcriptomics.

Nature metabolism·2025
Same author

More than meets the eye: mutation of the white gene in Drosophila has broad phenotypic and transcriptomic effects.

Genetics·2025
Same author

Integrative multi-omics analysis of metabolic dysregulation induced by occupational benzene exposure in mice.

The Science of the total environment·2025
Same author

Integrative multiomics analysis of metabolic dysregulation induced by occupational benzene exposure in mice.

bioRxiv : the preprint server for biology·2025
Same author

Single-embryo RNA sequencing for continuous and sex-specific gene expression analysis on Drosophila.

STAR protocols·2023

Related Experiment Video

Updated: Jul 8, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

How does noncoding transcription regulate Hox genes?

Adelheid Lempradl1, Leonie Ringrose

  • 1IMBA, Institute of Molecular Biotechnology GmbH, Vienna, Austria.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 18, 2008
PubMed
Summary
This summary is machine-generated.

Noncoding RNAs in Drosophila Hox gene regulation are key to understanding development. This review reconciles conflicting data by considering developmental timing, clarifying their role in gene silencing or activation.

More Related Videos

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Related Experiment Videos

Last Updated: Jul 8, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Noncoding RNAs, including those in Drosophila Hox complexes, have emerged as crucial regulators.
  • The precise function of these noncoding transcripts in Hox gene regulation remains debated, with evidence suggesting roles in both silencing and activation.
  • Recent discoveries of "hidden transcriptomes" highlight the significance of noncoding RNAs in complex organisms.

Purpose of the Study:

  • To review and synthesize current evidence on the role of noncoding RNAs in Drosophila Hox gene regulation.
  • To address the controversy regarding whether noncoding transcripts mediate gene silencing or activation.
  • To propose a framework for resolving conflicting experimental results by incorporating developmental timing.

Main Methods:

  • Literature review and synthesis of existing studies on noncoding RNAs and Hox gene regulation.
  • Analysis of experimental data considering the temporal dynamics of gene expression during development.
  • Evaluation of current models and exploration of alternative interpretations for observed phenomena.

Main Results:

  • Conflicting results regarding noncoding RNA function in Hox gene regulation can be reconciled by accounting for developmental timing.
  • Evidence suggests that the role of noncoding transcripts (silencing vs. activation) is context-dependent and varies with developmental stage.
  • Developmental timing provides a critical parameter for understanding the functional significance of noncoding RNAs in gene regulation.

Conclusions:

  • Noncoding RNAs play a significant, albeit complex, role in the precise regulation of Drosophila Hox genes.
  • Understanding the developmental context is essential for accurately interpreting the function of noncoding RNAs in gene regulation.
  • Further research incorporating temporal dynamics will be crucial for fully elucidating the mechanisms of noncoding RNA action in development.