Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enteral glutamine pretreatment does not decrease plasma endotoxin level induced by ischemia-reperfusion injury in

Arda Demirkan1, Erkin Orazakunov, Berna Savaş

  • 1Ankara University, School of Medicine, Ibni Sina Hospital, Department of Emergency Medicine, Sihhiye, Ankara, Turkey. ardademirkan@superonline.com

World Journal of Gastroenterology
|January 18, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatic steatosis is associated with HBsAg seroclearance in patients with chronic hepatitis B virus infection but it is also associated with disease progression.

Hepatology forum·2026
Same author

Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development.

Frontiers in immunology·2025
Same author

Histological disease progression in patients with metabolic dysfunction-associated steatotic liver disease using paired liver biopsy.

European journal of gastroenterology & hepatology·2025
Same author

Transformative insights from transcriptome analysis of colorectal cancer patient tissues: identification of four key prognostic genes.

PeerJ·2025
Same author

Cytomegalovirus Infections in Patients Diagnosed with Inflammatory Bowel Disease.

Infectious diseases & clinical microbiology·2025
Same author

Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans.

Nature communications·2024
Same journal

Lessons from extended induction and practical evidence for improving tofacitinib therapy in ulcerative colitis.

World journal of gastroenterology·2026
Same journal

Small animal <i>ex vivo</i> machine perfusion of the liver: A comprehensive literature review.

World journal of gastroenterology·2026
Same journal

Comparable remission and health care use in real-world inflammatory bowel disease patients initiating originator biologics <i>vs</i> biosimilars.

World journal of gastroenterology·2026
Same journal

Diagnosis and management of metabolic dysfunction-associated steatohepatitis in patients with chronic hepatitis B infection.

World journal of gastroenterology·2026
Same journal

Simultaneous treatment of concomitant achalasia coexisting with epiphrenic diverticulum: The practice of submucosal tunneling technique.

World journal of gastroenterology·2026
Same journal

Lianhe Xiaozhi ointment ameliorates metabolic dysfunction-associated steatotic liver disease <i>via</i> peroxisome proliferator-activated receptor alpha pathway activation.

World journal of gastroenterology·2026
See all related articles

Oral glutamine pretreatment appears to protect intestinal integrity against ischemia-reperfusion (I/R) injury in rats. However, it did not significantly alter histopathological damage or plasma endotoxin levels post-I/R.

Area of Science:

  • Gastroenterology
  • Surgical Research
  • Nutritional Science

Background:

  • Intestinal ischemia-reperfusion (I/R) injury compromises mucosal integrity.
  • Maintaining intestinal barrier function is crucial during I/R events.
  • Nutritional interventions are explored to mitigate I/R-induced damage.

Purpose of the Study:

  • To evaluate the protective effect of oral glutamine pretreatment on intestinal mucosal integrity in a rat model of I/R.
  • To assess if glutamine supplementation can prevent I/R-induced increases in intestinal permeability, histopathological damage, and endotoxemia.

Main Methods:

  • A rat model of intestinal ischemia-reperfusion (I/R) was utilized.
  • Animals received either oral glutamine (1 g/kg for 4 days) or a normal diet prior to I/R.

Related Experiment Videos

  • Intestinal permeability, histopathological changes, and plasma endotoxin levels were measured.

    • Main Results:

    • Intestinal I/R significantly increased intestinal permeability, plasma endotoxin, and histopathological damage.
    • Glutamine pretreatment significantly reduced intestinal permeability following I/R.
    • No significant differences were observed in plasma endotoxin levels or histopathological findings between glutamine-treated and control groups post-I/R.

    Conclusions:

    • Oral glutamine pretreatment demonstrates a protective effect on intestinal mucosal permeability during I/R injury in rats.
    • The protective effect of glutamine did not translate to significant improvements in histopathological outcomes or plasma endotoxin levels.
    • Further research may be needed to elucidate the mechanisms and optimal conditions for glutamine's role in I/R injury.