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Uteroglobin-related protein 1 gene -112G/a polymorphism and atopic asthma in Sicilian children

Luciana Rigoli1, Chiara Di Bella, Vincenzo Procopio

  • 1Department of Pediatrics, Medical School, University of Messina, Messina, Italy. luciana.rigoli@unime.it

Allergy and Asthma Proceedings
|January 19, 2008
PubMed

Insights

The uteroglobin-related protein 1 (UGRP1) -112G/A gene variant is not associated with atopic asthma in the Sicilian population. This study found no significant genetic link between this UGRP1 polymorphism and asthma development in the investigated group.

Area of Science:

  • Genetics
  • Pulmonology
  • Immunology

Background:

  • Uteroglobin-related protein 1 (UGRP1) is a secretory protein primarily found in the lung and trachea.
  • A promoter polymorphism (-112G to A) in the UGRP1 gene has been previously linked to asthma in Japanese populations.
  • Replication of this association in other populations is lacking.

Purpose of the Study:

  • To investigate the association between the UGRP1 gene -112G/A polymorphism and atopic asthma in the Sicilian population.
  • To determine if this specific UGRP1 gene variant contributes to the genetic predisposition of atopic asthma.

Main Methods:

  • Transmission Disequilibrium Test (TDT) was performed on 73 trios (asthmatic child and parents).
  • A case-control study compared 113 asthmatic children with 230 healthy Italian individuals.
  • Genotyping of the -112 G/A polymorphism was conducted using PCR-RFLP and direct sequencing.

Main Results:

  • The TDT showed no preferential transmission of the -112A allele from parents to asthmatic offspring.
  • No significant difference in the prevalence of the -112A allele or genotypes containing the A allele was observed between asthma cases and controls.
  • The -112G/A polymorphism did not demonstrate a statistically significant association with atopic asthma.

Conclusions:

  • The -112G/A polymorphism in the UGRP1 gene does not appear to play a significant role in the genetic susceptibility to atopic asthma in the Sicilian population.
  • These findings suggest that the previously reported association in the Japanese population may not be universally applicable.
  • Further research may be needed to explore other genetic factors influencing UGRP1 and asthma risk.

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