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Infant heart transplantation 1991.
F Bouchart1, S R Gundry, L L Bailey
1Loma Linda University Medical Center, Department of Surgery, California.
Clinical Transplants
|January 1, 1991
Summary
Pediatric heart transplantation in infants shows promising 79% 5-year survival, comparable to adults. Complex congenital heart disease was the primary indication, but organ donor shortages persist.
Area of Science:
- Cardiology
- Pediatric Surgery
- Immunology
Background:
- Infantile heart transplantation is a critical intervention for end-stage heart failure.
- Complex congenital heart disease is a leading indication for pediatric heart transplantation.
- Early outcomes and long-term survival data in infant heart recipients are essential.
Purpose of the Study:
- To evaluate the outcomes of orthotopic heart transplantation in infants.
- To assess early mortality and long-term survival rates.
- To analyze indications, donor-recipient matching, and immunosuppression protocols.
Main Methods:
- A retrospective analysis of 118 infant heart transplantations performed between November 1985 and June 1991.
- Inclusion criteria: recipients less than 1 year old.
- Data collection on indications, donor-recipient weight ratio, ischemic time, mortality, and survival.
Main Results:
- 118 infant heart transplantations were performed on 117 infants.
- Complex congenital heart disease accounted for 92% of indications.
- Early mortality was 10.2%, with a 5-year actuarial survival of 79%.
Conclusions:
- Infant heart transplantation outcomes are encouraging and comparable to adult results.
- Noninvasive techniques are effective for rejection diagnosis.
- The scarcity of organ donors remains a significant challenge in pediatric transplantation.