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Updated: Jul 8, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Group B Streptococcus and pregnancy: a review.

John W Larsen¹, John L Sever

¹The George Washington University, Washington, DC, USA. jlarsen@mfa.gwu.edu

American Journal of Obstetrics and Gynecology

|January 19, 2008

Summary

Group B Streptococcus (GBS) infections in newborns remain a significant perinatal threat. Intravenous antibiotic prophylaxis during labor effectively prevents vertical transmission, while PCR diagnostics offer rapid detection, though immunization remains challenging.

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Last Updated: Jul 8, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Area of Science:

Neonatal infections
Perinatal epidemiology
Microbiology

Background:

Group B Streptococcus (GBS) historically caused high neonatal sepsis rates (2/1000 live births, 50% fatality).
Despite advances, GBS persists as a leading cause of perinatal infection.
Previous interventions like early treatment and antibiotic prophylaxis reduced morbidity and mortality.

Purpose of the Study:

To review investigations and studies on Group B Streptococcus (GBS).
To highlight contributions to the diagnosis, treatment, and prevention of GBS disease.
To discuss the efficacy of antibiotic prophylaxis and emerging diagnostic technologies.

Main Methods:

Review of conducted investigations and related studies, including animal models (monkeys).
Analysis of the effectiveness of intravenous antibiotic prophylaxis during parturition.
Evaluation of polymerase chain reaction (PCR) diagnostic tests for GBS detection.

Main Results:

Intravenous antibiotic prophylaxis during parturition is effective in preventing vertical GBS transmission in animals and humans.
Polymerase chain reaction (PCR) tests show promise for rapid and accurate GBS detection.
Eradication of GBS colonization has not been achieved, and immunization remains a challenge.

Conclusions:

Antibiotic prophylaxis during labor is a key strategy for preventing GBS transmission.
Rapid diagnostic tests like PCR could revolutionize GBS detection at delivery.
Further research is needed to develop effective GBS immunization strategies.