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Intradermal antityphoid-antitetanus vaccination by jet injection

G Dimache1, M Croitoru, V Velea

  • 1Contacuzino Institute, Bucharest, Romania.

Roumanian Archives of Microbiology and Immunology
|April 1, 1991
PubMed

A lyophilized, heat-killed, phenol preserved typhoid vaccine (5 x 10(8) cells) suspended in 0.1 ml unadsorbed concentrated tetanus vaccine (10 Lf) was administered in man by intradermal route. This association of the two vaccines resulted in milder postvaccinal reactions: moreover, the immunological properties of typhoid vaccine, as certified by the passive protection test of the mouse with sera of the vaccines and the H and O agglutinin titres found in these immune sera, were perfectly conserved. Consequently, the mixed typhoid-tetanus vaccination in man by intradermal route is possible and advantageous for practical and economical reasons.

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