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Related Experiment Video

Updated: Jul 8, 2026

Localization, Identification, and Excision of Murine Adipose Depots

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Obesity and lipodystrophy--where do the circles intersect?

Farid F Chehab¹

¹University of California, San Francisco, Department of Laboratory Medicine, 185 Berry Street, Suite 290, San Francisco, California 94107-0134, USA. chehabf@labmed2.ucsf.edu

|January 19, 2008

Summary

This summary is machine-generated.

Adipose tissue

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Last Updated: Jul 8, 2026

Localization, Identification, and Excision of Murine Adipose Depots

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Area of Science:

Metabolic research
Cell biology
Endocrinology

Background:

Adipose tissue exhibits remarkable plasticity, undergoing hypertrophy and atrophy.
The lipid-filled adipocyte is central to this elasticity, storing triglycerides and serving as an energy reservoir.
Obesity and lipodystrophy are linked to insulin resistance.

Purpose of the Study:

To review recent studies on adipose tissue.
To explore central and peripheral mechanisms regulated by adipocyte-secreted factors.
To elucidate the role of these factors in insulin sensitivity and glucose uptake.

Main Methods:

Review of recent scientific literature.
Analysis of adipocyte-secreted factors including leptin, adiponectin, resistin, and retinol-binding protein 4.
Investigation of pathways controlling insulin sensitivity and glucose uptake.

Main Results:

Adipocyte-secreted factors play crucial roles in metabolic regulation.
Understanding these factors is key to addressing insulin resistance.
Recent studies have advanced knowledge of adipose tissue plasticity and its implications.

Conclusions:

Adipose tissue's unique elasticity is vital for energy homeostasis.
Adipocyte-secreted factors are critical mediators of insulin sensitivity.
Further research into these factors may unlock treatments for obesity, lipodystrophy, and insulin resistance.