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Hypothermia in VGKC antibody-associated limbic encephalitis
S Jacob1, S R Irani, Y A Rajabally
1Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.
Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) can present with episodic hypothermia and neuropathic pain. Immunosuppressive therapy effectively treated these novel symptoms and core LE features.
Area of Science:
- Neurology
- Immunology
- Neuroimmunology
Background:
- Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is an immunotherapy-responsive central nervous system disorder.
- The clinical spectrum of LE is not fully defined and may be under-diagnosed.
Observation:
- Four patients with VGKC-Ab-associated LE exhibited intermittent, episodic hypothermia.
- One patient experienced severe neuropathic pain preceding limbic symptoms.
Findings:
- Episodic hypothermia and neuropathic pain are novel presentations of VGKC-Ab-associated LE.
- These symptoms, along with amnesia and seizures, responded well to immunosuppressive therapy.
Implications:
- This study expands the known clinical spectrum of VGKC-Ab-associated LE.
- Recognizing these novel symptoms may improve diagnosis and management of LE.
- Highlights the efficacy of immunotherapy in treating a broader range of LE manifestations.
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