[Point mutation of c-Ha-ras oncogene in oral cancers]

After sub-sequence of c-Ha-ras oncogene in 11 Chinese oral cancers was amplified with in vitro DNA amplification technique, G----T mutation of c-Ha-ras oncogene at codon 12 was detected by specific mutated oligonucleotide probe, resulting in point mutation of c-Ha-ras oncogene at codon 12 in 4 out of 11 oral cancers which shows that c-Ha-ras oncogene is one of the genes associated with the development and progression of oral cancers, and point mutation may lead to activation of c-Ha-ras oncogene.