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[Histopathological analysis of 44 cases with oral candidiasis]
1School of Stomatology, Beijing Medical University.
Abstract:
44 cases of oral candidiasis were studied histopathologically. We have found out that the microabscess in superficial epithelium is the histologic symbol of oral candidiasis. So, for those cases with microabscess, PAS stain should be done in order to make definite diagnosis. Epithelial dysplasia was observed in 8 cases (18.2%). Clinically these 8 cases were chronic hyperplastic oral candidiasis, this means that the long term follow-up study should be done for those with chronic hyperplastic oral candidiasis. Inflammatory infiltration was related to the amount of candida. The more candida get into the epithelium, the heavier inflammation is.
Insights
Microabscesses in the superficial epithelium are a key indicator of oral candidiasis. Periodic acid-Schiff (PAS) staining aids definitive diagnosis, and chronic cases require long-term monitoring due to potential epithelial dysplasia.
Area of Science:
- Oral pathology
- Mycology
- Histopathology
Context:
- Oral candidiasis is a common opportunistic fungal infection.
- Accurate histopathological diagnosis is crucial for effective management.
- Understanding the relationship between Candida load and host response is important.
Purpose:
- To identify the key histopathological features of oral candidiasis.
- To evaluate the utility of Periodic acid-Schiff (PAS) staining in diagnosis.
- To assess the prevalence of epithelial dysplasia in chronic hyperplastic oral candidiasis and its implications.
Summary:
- Histopathological examination of 44 oral candidiasis cases revealed microabscesses in the superficial epithelium as a diagnostic hallmark.
- PAS staining is recommended for definitive diagnosis in cases presenting with microabscesses.
- Epithelial dysplasia was observed in 18.2% of cases, all clinically presenting as chronic hyperplastic oral candidiasis, necessitating long-term follow-up.
- Inflammatory infiltration correlated positively with the extent of Candida invasion into the epithelium.
Impact:
- Establishes microabscess as a key diagnostic marker for oral candidiasis.
- Recommends PAS staining for improved diagnostic accuracy.
- Highlights the need for vigilant monitoring of chronic hyperplastic oral candidiasis due to dysplasia risk.
- Provides insights into the inflammatory response to Candida infection in oral tissues.