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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Published on: July 3, 2013

Chronic renal failure in children of benin, Nigeria

Ibadin Okoegual Michael1, Ofovwe Egberue Gabreil

  • 1Department of Child Health, University of Benin Teaching Hospital, Benin City, Nigeria.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|January 19, 2008
PubMed

Insights

Pediatric chronic renal failure is often caused by glomerulonephritis and posterior urethral valves. High mortality rates in children with kidney disease are linked to limited treatment options and delayed diagnosis.

Area of Science:

  • Pediatric Nephrology
  • Renal Disease Epidemiology

Background:

  • Chronic renal failure (CRF) in children presents unique etiological and outcome challenges.
  • Understanding these patterns is crucial for improving pediatric kidney care.

Purpose of the Study:

  • To prospectively evaluate the etiology and outcomes of pediatric chronic renal failure.
  • To identify common causes, presenting symptoms, and mortality rates in referred pediatric cases.

Main Methods:

  • Prospective study of 24 children with renal disease (1997-2002).
  • Analysis of etiological factors, clinical presentations, and patient outcomes.
  • Calculation of incidence and prevalence rates.

Main Results:

  • Leading causes: glomerulonephritis (58.3%) and posterior urethral valve (33.3%).
  • Common symptoms included generalized and abdominal swelling, and paleness.
  • High mortality rate of 58.3% observed.
  • Late presentation and severely compromised renal function were frequent.

Conclusions:

  • Increased mortality in pediatric renal disease is attributed to limited renal replacement therapy facilities, poverty, and late referrals.
  • Urgent need for improved access to pediatric nephrology care and treatment options.
  • Addressing socio-economic factors is vital for better outcomes in children with kidney disease.

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