Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current status of the Gene-Tox Program.

A E Auletta1, M Brown, J S Wassom

  • 1U.S. Environmental Protection Agency, Office of Toxic Substances, Washington, DC 20460.

Environmental Health Perspectives
|December 1, 1991
PubMed
Summary

The U.S. Environmental Protection Agency's Gene-Tox Program systematically reviews genetic toxicology data for over 4000 chemicals. This comprehensive database aids in identifying potential human health hazards from chemical exposures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reflections on the impact of advances in the assessment of genetic risks of exposure to ionizing radiation on international radiation protection recommendations between the mid-1950s and the present.

Mutation research·2007
Same author

A toxicity evaluation and predictive system based on neural networks and wavelets.

Journal of chemical information and modeling·2007
Same author

Ionizing radiation and genetic risks XIV. Potential research directions in the post-genome era based on knowledge of repair of radiation-induced DNA double-strand breaks in mammalian somatic cells and the origin of deletions associated with human genomic disorders.

Mutation research·2005
Same author

Frederick J. de Serres: the Oak Ridge years (1955-1972).

Mutation research·1999
Same author

The L5178Y/tk+/- mouse lymphoma specific gene and chromosomal mutation assay a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program.

Mutation research·1998
Same author

Response to "Selecting chemicals and assays for assessing mammalian germ cell mutagenicity" [M.D. Shelby, Mutation Research, 352 (1996) 159-167].

Mutation research·1997

Area of Science:

  • Environmental Toxicology
  • Genetic Toxicology
  • Chemical Safety Assessment

Background:

  • The U.S. Environmental Protection Agency's Gene-Tox Program was established to address the need for standardized evaluation of genetic toxicology data.
  • Existing scientific literature on chemical genotoxicity was fragmented and required systematic review and analysis.

Purpose of the Study:

  • To review and evaluate existing assay systems in genetic toxicology.
  • To generate expert reviews of scientific literature on chemical genotoxicity.
  • To establish and evaluate a database for identifying human health hazards.

Main Methods:

  • Multiphased program involving selection of assay systems and expert panel reviews.
  • Evaluation of genetic toxicity data for relevance to human health hazards.

Related Experiment Videos

  • Ongoing review and updating of chemical data in selected assay systems.

    • Main Results:

    • Data on over 4000 chemicals across 27 assay systems are available.
    • Review data are published and accessible via the National Library of Medicine TOXNET system.
    • 45 Gene-Tox review papers have been published, with more in preparation.

    Conclusions:

    • The Gene-Tox Program provides a valuable resource for genetic toxicity data.
    • Observed differences with other databases are due to variations in chemical selection, protocols, and chemical class distributions.
    • The program contributes to understanding chemical impacts on human health through genetic toxicology.