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Updated: Jul 8, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
[Determination of buprenorphine in urine]
Solfrid Hegstad1, Asbjørg S Christophersen, Hassan Z Khiabani
1Nasjonalt folkehelseinstitutt, Divisjon for rettstoksikologi og rusmiddelforskning, Postboks 4404 Nydalen, 0403 Oslo. solfrid.hegstad@fhi.no
Abstract:
Buprenorphine is one of the drugs used for treatment of opioid-dependent patients enrolled in rehabilitation programs in Norway. Buprenorphine is metabolized in the liver by cytochrome P450 to the active metabolite norbuprenorphine, and further to buprenorphine-glucuronide and norbuprenorphine-glucuronide. The Division of Forensic Toxicology and Drug Abuse at the Norwegian Institute of Public Health has during the past 5 years received an increasing number of urine samples for buprenorphine analysis. All urine samples with question of buprenorphine have since August 2005 been analysed with a new method, which analyses the glucuronides of buprenorphine and norbuprenorphine in urine. This method is fast and simple and saves time and resources in our routine laboratory.
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