Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
ABC Transporters: Exporter01:31

ABC Transporters: Exporter

ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulation of Human Renal Transporters by Pregnancy-Related Hormones in Primary Proximal Tubular Epithelial Cells.

Metabolites·2026
Same author

Impact of the gut microbiome on hepatic cytochrome P450 3A4 (CYP3A4) in humanized pregnane X receptor-constitutive androstane receptor-CYP3A4/3A7 mice.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same author

Effect of proinflammatory cytokines on intestinal drug transporters in human enteroid monolayers.

Drug metabolism and disposition: the biological fate of chemicals·2025
Same author

Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms.

bioRxiv : the preprint server for biology·2025
Same author

Are Δ<sup>9</sup>-Tetrahydrocannabinol and Its Major Metabolites Substrates or Inhibitors of Placental or Human Hepatic Drug Solute-Carrier Transporters?

International journal of molecular sciences·2024
Same author

Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines.

The Journal of pharmacology and experimental therapeutics·2024

Related Experiment Video

Updated: Jul 8, 2026

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
11:02

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1

Published on: May 27, 2016

BCRP/ABCG2 in the placenta: expression, function and regulation.

Qingcheng Mao1

  • 1Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195-7610, USA. qmao@u.washington.edu

Pharmaceutical Research
|January 19, 2008
PubMed
Summary
This summary is machine-generated.

The placental efflux transporter BCRP (ABCG2) protects the fetus from drug toxicity by expelling harmful substances. Understanding BCRP

More Related Videos

Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis
10:13

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis

Published on: March 13, 2026

Related Experiment Videos

Last Updated: Jul 8, 2026

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
11:02

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1

Published on: May 27, 2016

Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis
10:13

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis

Published on: March 13, 2026

Area of Science:

  • Pharmacology and Toxicology
  • Maternal-Fetal Medicine
  • Molecular Biology

Background:

  • Maternal drug administration requires understanding placental transfer to assess fetal risk and optimize therapy.
  • Efflux transporters in the placenta are key determinants of fetal drug exposure.
  • The ATP-binding cassette efflux transporter BCRP (ABCG2) is highly expressed in placental syncytiotrophoblasts.

Purpose of the Study:

  • To review current knowledge on the expression, function, and regulation of placental BCRP (ABCG2).
  • To discuss the role of BCRP in protecting the fetus from xenobiotics and drug toxicity.
  • To explore the clinical significance of placental BCRP in pregnant women's drug therapy.

Main Methods:

  • Literature review synthesizing existing research on placental BCRP.
  • Analysis of studies on BCRP expression, function, polymorphisms, and regulation.
  • Discussion of clinical implications for drug therapy during pregnancy.

Main Results:

  • BCRP (ABCG2) is abundantly expressed in the apical membrane of placental syncytiotrophoblasts.
  • Evidence suggests BCRP actively expels drugs, xenobiotics, and metabolites, protecting the fetus.
  • BCRP's role in fetal protection is significant, though its precise physiological function requires further elucidation.

Conclusions:

  • Placental BCRP (ABCG2) plays a crucial role in fetal protection against drug-induced toxicity.
  • Understanding BCRP's expression, function, and regulation is vital for safe and effective drug therapy in pregnancy.
  • Further research into BCRP polymorphisms and clinical significance will enhance therapeutic strategies for pregnant women.