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Is joint hypermobility important in prepubertal children?
Pelin Yazgan1, Iclal Geyikli, Dost Zeyrek
1Department of Physical Medicine and Rehabilitation, School of Medicine, Harran University, PK:89, Sanliurfa, Merkez, Turkey. pyazgan@harran.edu.tr
Serum prolidase activity was lower in hypermobile children, suggesting a link to collagen metabolism. Joint hypermobility is common in children and associated with other musculoskeletal conditions.
Area of Science:
- Biochemistry
- Pediatrics
- Genetics
Background:
- Joint hypermobility is a condition characterized by excessive range of motion in joints.
- It can be associated with various musculoskeletal complaints and may have a genetic component.
- Understanding the underlying biochemical mechanisms, such as collagen metabolism, is crucial for characterizing this condition.
Purpose of the Study:
- To investigate serum prolidase activity in relation to collagen metabolism and joint hypermobility in prepubertal children.
- To determine the prevalence and characteristics of joint hypermobility in this age group.
Main Methods:
- Serum prolidase activity was measured spectrophotometrically.
- Joint hypermobility was assessed using the Beighton criteria.
- Children underwent comprehensive medical history and physical examinations.
Main Results:
- Serum prolidase levels were lower in the hypermobile group compared to controls, though not statistically significant (P > 0.05).
- A significant negative correlation was found between serum prolidase levels and Beighton scores (r = -0.295, P = 0.002).
- The prevalence of joint hypermobility (Beighton score >= 4) was 39.3%, with significant associations with pes planus, arthralgia, and parental musculoskeletal disorders.
Conclusions:
- Decreased serum prolidase activity may be linked to altered collagen metabolism in children with joint hypermobility.
- Joint hypermobility in children is prevalent and associated with several clinical signs and symptoms, warranting further investigation.
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