Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clozapine in China.

Y-L Tang1, P-X Mao, F Jiang

  • 1Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, China. ytang5@emory.edu

Pharmacopsychiatry
|January 19, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lower FEV<sub>1</sub> and gram-negative bacilli isolation as independent risk factors for exacerbations in post-TB bronchiectasis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same author

Thrombosis and bleeding outcomes with warfarin conversion to rivaroxaban during the COVID-19 pandemic.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

Relationships Between the Infrapatellar Fat Pad and Patellofemoral Joint Osteoarthritis Differ With Body Mass Index and Sex.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2025
Same author

Combined first-trimester screening vs non-invasive prenatal testing.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024
Same author

Correction to: A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET<sup>TM</sup> Plus platform.

The pharmacogenomics journal·2024
Same author

[Effect of birth parity on life expectancy and healthy life expectancy among rural women].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2024
Same journal

A Tribute to Prof. Jules Angst highlighting his Contributions to Clozapine.

Pharmacopsychiatry·2026
Same journal

Correction: Escitalopram and Clonazepam Affect Gasotransmitter-related Enzyme (nNOS, HO-2, CBS) Gene Expression in the Rat Brain.

Pharmacopsychiatry·2026
Same journal

Correction: Non-Response to Antidepressants: Risk Factors and Therapeutic Possibilities.

Pharmacopsychiatry·2026
Same journal

Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2026 - Pharmacokinetic, pharmacogenetic and clinical aspects.

Pharmacopsychiatry·2026
Same journal

Therapeutic Drug Monitoring of Cannabinoids: Therapeutic Reference Ranges for Delta-9-tetrahydrocannabinol in Medical Cannabis, Nabiximols, Dronabinol and Nabilone.

Pharmacopsychiatry·2026
Same journal

A Naturalistic Study on the Cost Reduction and Efficacy of Long-acting Antipsychotics in an Early Intervention Programme for Patients with Recent-onset Psychosis.

Pharmacopsychiatry·2026
See all related articles

Clozapine is widely used for schizophrenia and other disorders in China, with significant rates of leukopenia and agranulocytosis. Chinese psychiatrists should carefully consider clozapine

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Clozapine is a commonly prescribed antipsychotic in China.
  • China has the largest population undergoing clozapine treatment globally.
  • Research findings from China are of significant interest to Western psychiatrists.

Observation:

  • Clozapine is used for schizophrenia, mania, treatment-resistant depression, and drug abuse in China.
  • 25-60% of schizophrenia patients receive clozapine, sometimes as a first-line treatment.
  • The average daily clozapine dose ranges from 200 to 400 mg.

Findings:

  • Incidence of leukopenia is 3.92% and agranulocytosis is 0.21% in China.
  • Approximately one-third of reported agranulocytosis cases result in death.
  • Weight gain and clozapine-associated diabetes are frequently reported side effects.

Related Experiment Videos

Implications:

  • Clozapine remains a primary treatment for schizophrenia in China.
  • Chinese psychiatrists must prioritize monitoring for clozapine's toxic side effects.
  • Further research is needed to optimize clozapine use and safety in the Chinese population.