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Ankle Joint01:10

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Knee Joint01:23

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.

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Related Experiment Video

Updated: Jul 8, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

Alendronate-induced synovitis.

David P Gwynne Jones1, Ruth L Savage, John Highton

  • 1Department of Medical, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. david.gwynne-jones@stonebow.otago.ac.nz

The Journal of Rheumatology
|January 19, 2008
PubMed
Summary
This summary is machine-generated.

Alendronate, a medication for osteoporosis, may cause synovitis or arthritis in some patients. Symptoms often returned when the drug was reintroduced, suggesting a link.

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Area of Science:

  • Rheumatology
  • Pharmacology
  • Clinical Medicine

Background:

  • Osteoporosis management frequently involves bisphosphonates like alendronate.
  • Synovitis and arthritis are common conditions with diverse etiologies.
  • Identifying drug-induced joint inflammation is crucial for patient care.

Observation:

  • Seven cases of synovitis or polyarthritis were observed following alendronate initiation.
  • These cases were sourced from clinical practice and pharmacovigilance reports.
  • Patients presented with joint inflammation without evidence of other specific arthropathies.

Findings:

  • No patients had rheumatoid arthritis, pyrophosphate arthropathy, or seronegative arthritis.
  • Five out of seven patients experienced symptom recurrence upon rechallenge with alendronate.
  • Alendronate was identified as a potential cause of synovitis/polyarthritis in these cases.

Implications:

  • Clinicians should consider alendronate as a potential cause of new-onset synovitis or polyarthritis.
  • Further investigation into the mechanism of alendronate-induced arthropathy is warranted.
  • This finding aids in the differential diagnosis of joint inflammation in patients on osteoporosis therapy.