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Premature thelarche in Macedonia: a three-year follow-up
M Krstevska-Konstantinova1, M Kocova, Z Gucev
1Department of Endocrinology and Genetics, Pediatric Clinic, Medical Faculty, Skopje, Macedonia. marina@lancom.com.mk
Introduction:
Premature thelarche presents as an appearance of breasts and glandular tissue in girls before the age of 8 years. It is mostly a benign and transitory variation of premature sexual development.
Aim Of The Study:
We evaluated a group of girls with premature thelarche for clinical and auxologic characteristics for a period of three years. We investigated the duration of the condition and eventual progression toward true idiopathic central precocious puberty.
Patients, Materials, Methods:
At the Department of Endocrinology and Genetics at the Pediatric Clinic in Skopje, 127 girls with premature thelarche, from all over the country, were analyzed and followed-up for a period of 3 years (2000-2003).
Results And Conclusions:
Premature thelarche as a partial form of premature sexual development, in our study included 98 girls, and showed to be a benign condition, the girls are with normal height, slightly elevated weight, but with increased bone maturation and height velocity in the first year. A progression toward central precocious puberty was not registered. The duration of the condition was about two years in most of the girls, with a regression of enlarged breasts in smaller patients and with occurrence of normal puberty in older patients (Tab. 1, Fig. 3, Ref. 16). Full Text (Free, PDF) www.bmj.sk.
