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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Related Experiment Video

Updated: Jul 8, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

What next for preimplantation genetic screening?

Joyce Harper1, Karen Sermon, Joep Geraedts

  • 1UCL Centre for PGD, Institute for Women's Health, University College London, 86-96 Chenies Mews, WC1E6HX London, UK. joyce.harper@ucl.ac.uk

Human Reproduction (Oxford, England)
|January 22, 2008
PubMed
Summary

Preimplantation genetic screening (PGS) aims to identify normal embryos but recent trials for advanced maternal age show no live birth benefit. Further well-designed trials are needed to clarify PGS effectiveness in fertility treatments.

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Last Updated: Jul 8, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Embryology

Background:

  • Preimplantation genetic screening (PGS) is utilized to select chromosomally normal embryos for subfertile patients.
  • Key indications include advanced maternal age, recurrent implantation failure, recurrent miscarriages, and severe male factor infertility.

Purpose of the Study:

  • To evaluate the effectiveness of preimplantation genetic screening (PGS) in improving live birth rates.
  • To address the ongoing debate regarding the clinical utility of PGS.

Main Methods:

  • Review of published non-randomized studies on PGS.
  • Analysis of two recent randomized controlled trials (RCTs) focusing on patients with advanced maternal age.

Main Results:

  • Non-randomized studies often report increased implantation and/or decreased miscarriage rates with PGS.
  • Two recent RCTs in advanced maternal age patients found no significant benefit of PGS on live birth rates.

Conclusions:

  • Current evidence from RCTs does not support the routine use of PGS for improving live birth rates in patients with advanced maternal age.
  • Well-designed and executed randomized clinical trials are essential to definitively determine the usefulness of PGS.