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Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
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Predicting disulfide bond connectivity in proteins by correlated mutations analysis

Rotem Rubinstein1, Andras Fiser

  • 1Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. rrubinst@aecom.yu.edu

Bioinformatics (Oxford, England)
|January 22, 2008
PubMed
Summary

Predicting disulfide bond connectivity in proteins is aided by analyzing correlated mutations. This method accurately identifies cysteine pairs that form disulfide bonds, improving protein structure and function annotation.

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