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Iatrogenic pulse granuloma detected at prostatectomy
Roy Nambudripad1, Navneet Narula, Mark Li-cheng Wu
1Department of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, Irvine, California.
International Journal of Surgical Pathology
|January 22, 2008
Summary
This study describes a rare pulse granuloma caused by vegetable matter displaced during a transrectal prostate biopsy. This finding highlights a novel etiology for this peculiar pathological reaction.
Area of Science:
- Pathology
- Urology
Background:
- Pulse granulomas are reactive lesions to vegetable matter, presenting as hyaline rings, and can occur orally or extraorally.
- Recognizing pulse granulomas is crucial due to their potential to mimic neoplasia and resemble hyaline vasculopathy.
Observation:
- A unique case of pulse granuloma in the periprostatic soft tissue of a 55-year-old man post-prostatectomy for adenocarcinoma was identified.
- Microscopic examination revealed vegetable matter within the granuloma, consistent with prior transrectal prostatic core biopsies.
Findings:
- Vegetable matter from transrectal biopsies was identified as the likely nidus for the development of the periprostatic pulse granuloma.
- This represents the first documented instance of a pulse granuloma attributed to a biopsy procedure and located in the periprostatic region.
Implications:
- This case expands the known causes and locations of pulse granulomas.
- It underscores the importance of considering iatrogenic factors, such as biopsy-induced displacement of foreign material, in the differential diagnosis of granulomatous inflammation.