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Low amplitude daily changes in reflex ventilatory response to progressive isocapnic hypoxia
M Siekierka1, M Tafil-Klawe, W Adamczyk
1Department of Physiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Abstract:
Daily changes in reflex ventilatory responses to hypoxia were studied in 56 young healthy men participated. A rebreathing technique--progressive isocapnic hypoxia--was used to measure hypoxic chemoreflex reactivity. The measurements were repeated every 3 hours during a 24-hour period. The ventilatory response to hypoxia--analyzed as the relationships (slope) MV/SaO2 (minute ventilation/arterial oxygen blood saturation) and P0.1/SaO2 (mouth occlusion pressure/oxygen arterial blood saturation) remained relatively stable throughout the examined period exhibiting low-amplitude differences from one another with the maximum variation at 12:00 hours.
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