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Hypertension risk in idiopathic hyperCKemia
Lizzy M Brewster1, Sjoerd van Bree, Jaap C Reijneveld
1Department of Internal and Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. l.m.grewster@amc.uva.nl
Journal of Neurology
|January 22, 2008
Summary
Individuals with idiopathic hyperCKemia face a significantly higher risk of developing hypertension. Early screening for high blood pressure in these patients is crucial for timely intervention.
Area of Science:
- Neurology
- Cardiology
- Biochemistry
Background:
- Idiopathic hyperCKemia, characterized by elevated serum creatine kinase, is often considered benign.
- Previous population studies indicated a correlation between higher creatine kinase levels and increased blood pressure.
Purpose of the Study:
- To investigate the prevalence of hypertension in individuals with idiopathic hyperCKemia compared to the general population.
- To determine if idiopathic hyperCKemia is an independent risk factor for hypertension.
Main Methods:
- A case-control study involving 46 participants with idiopathic hyperCKemia and 22,612 population controls.
- Data collected included blood pressure measurements, demographics, and body mass index.
- Statistical analysis using odds ratios to compare hypertension prevalence.
Main Results:
- 48% of individuals with idiopathic hyperCKemia were hypertensive versus 19% in the control group.
- This represents an odds ratio of 3.9 (95% CI, 2.2 to 6.9) before adjustment and 2.0 (1.1 to 3.8) after adjustment.
- The association remained significant after accounting for sex, age, and BMI.
Conclusions:
- Idiopathic hyperCKemia is associated with a substantially increased risk of hypertension.
- Elevated tissue creatine kinase activity may contribute to hypertension through enhanced ATP buffering capacity.
- Screening and monitoring for hypertension in patients with idiopathic hyperCKemia are recommended.
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