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Updated: Jul 8, 2026
04:47
Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
Published on: October 27, 2023
Ankylosing spondylitis and Sweet's syndrome.
Daniel Wendling1, Michel Léaustic, Eric Toussirot
1Department of Rheumatology, University of Franche-Comté, University Teaching Hospital Minjoz, 25030 Besançon, France. dwendling@chu-besancon.fr
Clinical Rheumatology
|January 22, 2008
Summary
This case study highlights a rare instance of Sweet's syndrome developing in a patient with ankylosing spondylitis (AS), even without the common human leukocyte antigen B 27 marker. This association is seldom reported, offering new insights into AS comorbidities.
Area of Science:
- Rheumatology and Dermatology
- Clinical Case Study
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
- Skin manifestations in AS are typically psoriasis-type lesions.
- Human leukocyte antigen B 27 (HLA-B27) is a genetic marker often associated with AS.
Observation:
- A woman diagnosed with AS (HLA-B27 negative) developed a febrile skin condition after 20 years.
- The skin disease was histologically confirmed as Sweet's syndrome.
- No other underlying systemic conditions were identified.
Findings:
- This report details a rare co-occurrence of Sweet's syndrome in a patient with ankylosing spondylitis.
- Only one prior case linking these conditions has been documented in medical literature.
- The case underscores the potential for atypical skin manifestations in AS.
Implications:
- This case expands the understanding of potential dermatological complications in ankylosing spondylitis.
- It suggests a possible, though rare, link between AS and Sweet's syndrome, irrespective of HLA-B27 status.
- Further research may elucidate the underlying mechanisms connecting these inflammatory conditions.
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