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Toxicity of Anllóns River sediment extracts using microtox and the zucconi phytotoxicity test

R Devesa-Rey1, A B Moldes, F Díaz-Fierros

  • 1Dpto. Edafología y Química Agrícola, Facultad de Farmacia, USC, Santiago de Compostela, Spain. rosadrey@usc.es

Bulletin of Environmental Contamination and Toxicology
|January 22, 2008
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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...