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Related Experiment Videos

Immunity in cattle vaccinated against ringworm.

A Rybnikár1, J Chumela, V Vrzal

  • 1Bioveta, Ivanovice na Hané, Czechoslovakia.

Mycoses
|September 1, 1991
PubMed
Summary
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This study evaluated a live, freeze-dried ringworm vaccine in calves. The vaccine demonstrated high efficacy, protecting nearly all calves and preventing severe lesions, with immunity lasting over a year.

Area of Science:

  • Veterinary immunology
  • Dermatology
  • Microbiology

Background:

  • Ringworm (dermatophytosis) is a common fungal infection in cattle.
  • Economic losses due to ringworm in livestock are significant.
  • Effective vaccines are crucial for controlling ringworm outbreaks.

Purpose of the Study:

  • To assess the protective efficacy of a live, freeze-dried ringworm vaccine in calves.
  • To compare the vaccine's performance against a virulent challenge strain of Trichophyton verrucosum.
  • To evaluate the duration of immunity conferred by the vaccine.

Main Methods:

  • A total of 422 calves were used in the study.
  • Vaccinated calves received a live, freeze-dried vaccine.
  • Calves were challenged with Trichophyton verrucosum via epicutaneous inoculation.

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  • Clinical signs and lesion severity were monitored post-challenge.

    • Main Results:

    • 99-100% of vaccinated calves were fully protected from day 28 post-revaccination.
    • Only 4.4-9.5% of challenged calves showed mild clinical signs.
    • Immunity persisted for at least one year.
    • Control calves exhibited extensive mycotic lesions.

    Conclusions:

    • The live, freeze-dried ringworm vaccine provides high and comparable protective properties.
    • The vaccine effectively prevents severe clinical signs and lesions.
    • Long-lasting immunity against ringworm is achieved with this vaccine.