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Updated: Jul 8, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Neuromodulators for migraine prevention
1University of Pittsburgh Headache Center, Pittsburgh, PA 15213, USA.
Headache
|January 22, 2008
Summary
Migraine is a debilitating neurological disorder impacting daily life. Effective treatment involves open communication and therapies like divalproex sodium and topiramate to prevent debilitating headache cycles.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a debilitating neurological condition causing severe headaches and distress.
- Its impact on daily functioning and productivity is significant, often assessed by tools like the Migraine-Specific Questionnaire.
Purpose of the Study:
- To emphasize the importance of patient-clinician dialogue regarding migraine's impact on daily life.
- To discuss appropriate acute and preventive therapies for managing chronic migraine.
Main Methods:
- Review of assessment tools for migraine impact (e.g., Migraine Disability Assessment questionnaire).
- Discussion of FDA-approved and non-approved neuromodulators for migraine prophylaxis.
- Emphasis on medication titration and management of adverse events.
Main Results:
- Divalproex sodium and topiramate are FDA-approved for migraine prevention.
- Other neuromodulators like gabapentin and zonisamide are also used.
- Preventive therapies require 2-3 months for efficacy assessment.
Conclusions:
- Open communication between patients and clinicians is crucial for determining optimal migraine treatment.
- Appropriate acute and preventive therapies can break the migraine cycle and improve patient quality of life.
- Careful medication titration and adverse event management are essential for successful migraine prophylaxis.
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