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Related Experiment Video

Updated: Jul 8, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Complex dermoscopic pattern: a potential risk marker for melanoma.

J B Lipoff¹, A Scope, S W Dusza

¹Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, U.S.A.

The British Journal of Dermatology

|January 22, 2008

Summary

This summary is machine-generated.

Dermoscopic patterns, particularly a complex global pattern with network and globules, are linked to increased melanoma risk. This suggests dermoscopy offers a more precise melanoma risk assessment than clinical evaluation alone.

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A 3D Organotypic Melanoma Spheroid Skin Model

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Last Updated: Jul 8, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Area of Science:

Dermatology
Oncology
Medical Imaging

Background:

Dysplastic nevi are established melanoma risk factors, but risk estimates vary.
Dermoscopy enables detailed classification of nevi based on global patterns.

Purpose of the Study:

To evaluate dermoscopic images of nevi in melanoma patients and controls.
To identify dermoscopic patterns associated with melanoma risk.

Main Methods:

Dermoscopic images of 187 nevi from 20 melanoma patients and 150 nevi from 20 controls were analyzed.
Complex global pattern defined as network and globules, with or without structureless areas.

Main Results:

Complex global dermoscopic pattern was more frequent in melanoma patients (OR 2.9, P=0.003).
Globules were more frequent in patients (OR 2.3, P=0.0001), while dots were inversely associated with melanoma (OR 0.5, P=0.002).

Conclusions:

Dermoscopic patterns may be more robust and specific melanoma risk markers than clinical nevus phenotype.
Pilot data indicate potential for improved melanoma risk stratification using dermoscopy.