[The relationship between coronary atherosclerotic stenosis and cerebral atherosclerotic stenosis]
Jia-ping Wei1, Kang Li, Hong Zhao
1Department of Cardiology, Xuan Wu Hospital, Capital University of Medical Sciences, Beijing 100053, China.
Insights
The severity of coronary artery stenosis parallels that of carotid/cerebral artery stenosis in patients with coronary artery disease and cerebral ischemia. This suggests a link between blockages in these major arteries.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Vascular Biology
Background:
- Coronary artery disease (CAD) and cerebrovascular disease often coexist.
- Atherosclerotic stenosis in different vascular beds may share common etiological factors.
Purpose of the Study:
- To investigate the relationship between the extent of coronary artery stenosis and carotid/cerebral atherosclerotic stenosis.
- To assess the correlation between stenosis severity in these two major arterial systems.
Main Methods:
- Carotid/aortocranial and coronary angiography were performed in 34 patients with CAD and symptomatic cerebral ischemia.
- Patients were categorized based on the degree of arterial stenosis (light, moderate, severe).
Main Results:
- A parallel relationship was observed between coronary artery stenosis and carotid/vertebral artery stenosis.
- Severe coronary stenosis was associated with severe cerebrovascular stenosis in 92% of cases.
- Moderate to severe stenosis in both coronary and cerebral arteries correlated with increased cardiovascular and cerebrovascular events, and mortality.
Conclusions:
- The incidence and severity of coronary artery stenosis are parallel to carotid artery or vertebral artery stenosis.
- Findings highlight the interconnectedness of atherosclerosis in the coronary and cerebrovascular systems.
Objective:
To observe the relationship between coronary and carotid/cerebral atherosclerotic stenosis.
Methods:
Carotid/aortocranial angiography and coronary angiography were performed in 34 CAD patients complicated with symptomatic cerebral ischemia. Patients were divided into 3 subgroups according to the extent of arterial stenosis determined by angiography. There were 5 light, 4 moderate and 25 severe stenosis determined by coronary angiography and there were 6 light, 6 moderate and 24 severe stenosis determined by carotid/aortocranial angiography.
Results:
The extent of coronary artery stenosis was parallel to the carotid artery or vertebral artery stenosis. Twenty-four patients out of 25 patients with severe coronary stenosis had severe cerebrovascular stenosis (P = 0.873). The coincident rate was as high as 92% for patients with moderate or severe cerebrovascular stenosis whose Califf risk scores of coronary artery were more than or equal to 2. The follow-up study showed the incidence of cardiovascular event and cerebrovascular event increased significantly in the patients with moderate to severe coronary and cerebral arteries stenosis and 3 patients with severe stenosis found in both coronary and cerebral arteries died during follow up.
Conclusion:
The incidence and severity of coronary artery stenosis is parallel with carotid artery or vertebral artery stenosis.
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