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Updated: Jul 8, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
[Diagnosis and management of nail psoriasis]
1Unidad de Psoriasis y Fototerapia. Servicio de Dermatología. Hospital Universitario Sagrado Corazón. Barcelona. Unidad Docente de la Universidad de Barcelona. Barcelona. España. ez.reg@terra.es
Abstract:
Nail psoriasis has traditionally been considered as one of the most difficult forms of psoriasis to treat. The most recent studies have found a higher prevalence of fungal infections in psoriatic nails and therefore cultures before and during treatment are necessary. Over the last few years, novel psoriatic therapies have been developed, some of which are effective for both skin and nail lesions (cyclosporine and biologic agents). Of the topical agents, vitamin D and A derivatives as well as nail lacquer containing 8 % clobetasol propionate can help improve lesions of both the nail bed and matrix.
Insights
Nail psoriasis is challenging to treat, but new therapies are emerging. Recent studies highlight the need for fungal cultures due to higher infection rates in psoriatic nails.
Area of Science:
- Dermatology
- Mycology
Context:
- Nail psoriasis presents significant treatment challenges.
- Fungal infections are increasingly recognized in psoriatic nails, necessitating diagnostic cultures.
- Recent advancements offer new therapeutic options for nail psoriasis.
Purpose:
- To review current understanding and treatment strategies for nail psoriasis.
- To emphasize the role of fungal infections in nail psoriasis management.
- To discuss novel systemic and topical therapies for nail psoriasis.
Summary:
- Nail psoriasis is notoriously difficult to manage.
- Fungal co-infections are common in psoriatic nails, requiring cultures for accurate diagnosis and treatment.
- Systemic treatments like cyclosporine and biologics, along with topical vitamin D/A derivatives and 8% clobetasol propionate nail lacquer, show promise for improving nail bed and matrix lesions.
Impact:
- Improved diagnostic approaches for nail psoriasis, incorporating fungal cultures.
- Enhanced therapeutic strategies combining systemic and topical agents for better patient outcomes.
- Potential for novel treatments to address both skin and nail manifestations of psoriasis.
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