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Updated: Jul 8, 2026

Tissue Engineering of the Intestine in a Murine Model

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

Improved survival in a multidisciplinary short bowel syndrome program.

Biren P Modi¹, Monica Langer, Y Avery Ching

¹Center for Advanced Intestinal Rehabilitation (CAIR), Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

Journal of Pediatric Surgery

|January 22, 2008

Summary

A multidisciplinary intestinal rehabilitation program significantly improved survival rates for pediatric patients with short bowel syndrome (SBS). This integrated approach enhances care coordination and outcomes for children facing this complex condition.

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Area of Science:

Pediatric gastroenterology and surgery
Intestinal rehabilitation and failure
Clinical outcomes and survival analysis

Background:

Pediatric short bowel syndrome (SBS) presents significant management challenges and high mortality rates.
Established in 1999, a multidisciplinary pediatric intestinal rehabilitation program aimed to address these challenges.
The program integrated specialized care from surgery, gastroenterology, nutrition, pharmacy, nursing, and social work.

Purpose of the Study:

To evaluate the impact of a multidisciplinary approach on survival rates in pediatric patients with severe SBS.
To compare outcomes of patients managed by the new program with a historical control group.

Main Methods:

Retrospective review of medical records for severe SBS patients treated from 1999-2006 (n=54).
Comparison with a historical control group (n=30) treated from 1986-1998.
Analysis included intestinal length, bilirubin levels, enteral nutrition achievement, and survival rates.

Main Results:

No significant difference in mean residual small intestinal length or peak direct bilirubin between groups.
Full enteral nutrition was achieved in 67% of patients in both the multidisciplinary group and the historical control group.
The multidisciplinary program demonstrated a significantly higher overall survival rate (89%) compared to historical controls (70%, P < .05).

Conclusions:

A multidisciplinary intestinal rehabilitation program facilitates integrated care for pediatric SBS patients.
This coordinated approach, encompassing surgical, medical, and nutritional management, is associated with improved survival.
The findings support the effectiveness of a multidisciplinary model in managing severe pediatric short bowel syndrome.