Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pilot study of screening method for pancreatic cancer using lipidomic profiling of plasma or serum.

Communications medicine·2026
Same author

Maintenance Treatment for Type 1 Autoimmune Pancreatitis: Effectiveness and Development of the PrescrAIP Relapse Prediction Model.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2025
Same author

Current Clinical Assessment of Prognosis of Chronic Pancreatitis.

Journal of gastrointestinal and liver diseases : JGLD·2025
Same author

Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions.

United European gastroenterology journal·2025
Same author

Acute pancreatitis as a risk factor of chronic pancreatitis and pancreatic cancer. An overview.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia·2024
Same author

Gut microbio-me and pancreatic cancer.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2024

Related Experiment Video

Updated: Jul 8, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Autoimmune pancreatitis.

Petr Dite1, Ivo Novotny, Jan Trna

  • 1Department of Hepatogastroenterology, University Hospital, Jihlavska 20, 625 00 Brno, Czech Republic. pdite@med.muni.cz

Best Practice & Research. Clinical Gastroenterology
|January 22, 2008
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis is a T-cell-mediated disease with characteristic imaging and serological findings. Early diagnosis is crucial for appropriate management and differentiating it from pancreatic cancer.

More Related Videos

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Related Experiment Videos

Last Updated: Jul 8, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Autoimmune pancreatitis (AIP) is a chronic pancreatic condition of presumed autoimmune origin.
  • It presents with distinct clinical, serological, histomorphological, and imaging features.
  • AIP is characterized by T-cell-mediated lymphoplasmacytic infiltration and fibrosis of pancreatic tissue.

Purpose of the Study:

  • To summarize the diagnostic criteria and clinical presentation of autoimmune pancreatitis.
  • To highlight the challenges in diagnosing AIP due to the lack of specific biomarkers.
  • To emphasize the importance of considering AIP in the differential diagnosis of pancreatic masses and obstructive jaundice.

Main Methods:

  • Review of clinical, serological, histomorphological, and imaging features of AIP.
  • Discussion of diagnostic criteria, including Japan Pancreas Society and HISORt criteria.
  • Analysis of differential diagnosis, particularly with pancreatic cancer.

Main Results:

  • Elevated serum IgG or IgG4 and specific antibodies are common but not specific.
  • Diagnostic criteria involve antibodies, pancreatic enlargement, duct narrowing, lymphoplasmacytic infiltration, and response to steroids.
  • HISORt criteria integrate imaging, organ involvement, IgG4 levels, and histopathology.
  • AIP can be associated with diabetes mellitus and exocrine dysfunction.
  • Jaundice and pancreatic mass are frequent signs, complicating differential diagnosis with pancreatic cancer.

Conclusions:

  • Autoimmune pancreatitis requires a comprehensive diagnostic approach combining clinical, serological, imaging, and histopathological findings.
  • Accurate diagnosis is essential to differentiate AIP from pancreatic cancer, especially in elderly males with obstructive jaundice and pancreatic mass.
  • Considering AIP in the differential diagnosis can prevent unnecessary surgical interventions.