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The DVR gene family in embryonic development
K M Lyons1, C M Jones, B L Hogan
1Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232.
Trends in Genetics : TIG
|November 1, 1991
Summary
The DVR gene family, including bone morphogenetic proteins, encodes secreted factors crucial for development. These DVR proteins act in a signaling cascade for inductive tissue interactions.
Area of Science:
- Developmental Biology
- Molecular Genetics
Background:
- The DVR gene family comprises over 15 members.
- These genes encode secreted proteins homologous to transforming growth factor beta.
- Examples include Drosophila decapentaplegic and Xenopus Vg1.
Purpose of the Study:
- To investigate the role of DVR proteins in developmental signaling.
- To understand the function of DVR proteins as extracellular signaling molecules.
Main Methods:
- Genetic analysis
- Biochemical assays
Main Results:
- DVR proteins are closely related to transforming growth factor beta.
- Evidence suggests DVR proteins function in a signaling cascade.
- This cascade mediates inductive tissue interactions during development.
Conclusions:
- DVR proteins are key extracellular signaling molecules.
- They play a critical role in mediating developmental tissue interactions.