Antiphospholipid syndrome in pregnancy

Area of Science:

• Reproductive Medicine
• Hematology
• Immunology

Background:

• Recurrent miscarriage affects numerous women, often linked to thrombotic and hemostatic disorders.
• Antiphospholipid syndrome is a significant cause of recurrent pregnancy loss.

Purpose of the Study:

• To present a streamlined, cost-effective evaluation protocol for recurrent miscarriage.
• To optimize diagnostic and therapeutic strategies for women with recurrent pregnancy loss and suspected antiphospholipid syndrome.

Main Methods:

• Systematic evaluation of 351 women referred for thrombosis and hemostasis assessment after recurrent miscarriages.
• Description of a specific clinical flow protocol for diagnosis and management.
• Review of treatment outcomes for antiphospholipid syndrome in recurrent miscarriage patients.

Main Results:

• The protocol aims to maximize diagnostic success while minimizing evaluation costs.
• It provides a framework for identifying underlying causes of recurrent miscarriage.
• The study discusses outcomes of the proposed protocol and existing treatments for antiphospholipid syndrome.

Conclusions:

• An optimized evaluation protocol can improve diagnostic yield for recurrent miscarriage.
• Effective management of antiphospholipid syndrome is crucial for successful pregnancy outcomes.
• Cost-effective evaluation is achievable without compromising diagnostic accuracy.