Related Experiment Video
Updated: Jul 8, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and
João Lavrado1, Alexandra Paulo, Jiri Gut
1iMed, CECF, Faculty of Pharmacy, University of Lisbon, Av Prof. Gama Pinto, 1649-003 Lisbon, Portugal.
Abstract:
A series of cryptolepine derivatives has been synthesized through the incorporation of short basic side-chains in the C-11 position of the 10H-indolo[3,2-b]quinoline scaffold. Their antiplasmodial activity was evaluated in vitro against the chloroquine resistant Plasmodium falciparum W2 strain, showing IC(50) values between 22 and 184 nM, while their cytotoxicity was assessed using HUVEC cells, revealing three compounds with a selectivity ratio higher than 10. The most selective of these derivatives, 4d, with a selectivity ratio of 46, was also the least cytotoxic of the series.
More Related Videos
08:48Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
09:13Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases
Published on: November 22, 2024
Related Concept Videos
Anthelminthic Agents
Antiprotozoal Agents
Antifungal Agents
Antiviral Nucleoside Inhibitors
Physical Properties of Amines
Inhibitors of Bacterial DNA Synthesis