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Updated: Jul 8, 2026
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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Cryptogenic stroke: time to determine aetiology
F Guercini1, M Acciarresi, G Agnelli
1Stroke Unit and Division of Cardiovascular Medicine, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy. fguercini@libero.it
Journal of Thrombosis and Haemostasis : JTH
|January 23, 2008
Summary
Cryptogenic strokes, often unexplained, are not benign and carry higher recurrence risks. Identifying stroke causes, like patent foramen ovale, is crucial for prevention, especially in younger patients.
Area of Science:
- Neurology
- Cardiology
- Vascular Medicine
Background:
- Cryptogenic strokes account for 30-40% of all strokes.
- Previously considered benign, recent studies indicate higher recurrence and adverse outcomes.
- Determining stroke aetiology is vital for preventing recurrence, particularly in young individuals.
Purpose of the Study:
- To review new evidence on the causes of cryptogenic stroke.
- To focus on patent foramen ovale and aortic arch atheroma as potential causes.
- To highlight the importance of etiological diagnosis in stroke management.
Main Methods:
- Literature review of recent studies on cryptogenic stroke.
- Analysis of etiological factors including patent foramen ovale and aortic arch atheroma.
- Focus on diagnostic challenges and implications for patient outcomes.
Main Results:
- Cryptogenic stroke is associated with increased long-term adverse outcomes and recurrence rates.
- Patent foramen ovale and aortic arch atheroma are significant etiological considerations.
- Incomplete diagnostic work-up can lead to undetermined stroke causes.
Conclusions:
- Re-evaluation of cryptogenic stroke as a non-benign condition is necessary.
- Thorough etiological investigation is essential for effective stroke prevention strategies.
- Identifying specific causes like PFO and atheroma improves risk stratification and treatment.
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