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Related Concept Videos

Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Genomic DNA in Eukaryotes00:58

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Replication in Eukaryotes01:29

Replication in Eukaryotes

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Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Related Experiment Video

Updated: Jul 8, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Genes encoding longevity: from model organisms to humans.

Maris Kuningas1, Simon P Mooijaart, Diana van Heemst

  • 1Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. m.kuningas@lumc.nl

Aging Cell
|January 23, 2008
PubMed
Summary
This summary is machine-generated.

Genetic variations influence lifespan, but their impact diminishes with evolutionary complexity. Human lifespan likely involves complex genetic networks and environmental interactions, making direct extrapolation from model organisms challenging.

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Last Updated: Jul 8, 2026

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Published on: August 16, 2017

Area of Science:

  • Genetics
  • Aging Research
  • Evolutionary Biology

Background:

  • Gene variations significantly impact lifespan in model organisms.
  • Identified genes regulate metabolism, maintenance, and repair, minimizing age-related damage.
  • Understanding conserved genes is crucial for aging research.

Purpose of the Study:

  • To describe evolutionary conserved genes involved in lifespan regulation across species.
  • To explore discrepancies in lifespan gene findings between model organisms and humans.
  • To assess the applicability of model organism findings to human populations.

Main Methods:

  • Review of existing literature on genetic regulation of lifespan.
  • Comparative analysis of gene function and impact across evolutionary scales.
  • Discussion of factors complicating extrapolation of findings to humans.

Main Results:

  • The impact of individual genes on lifespan generally decreases with increasing evolutionary complexity.
  • Human lifespan regulation is likely influenced by complex genetic networks rather than single genes.
  • Phenotypic expression is highly context-dependent, differing between lab and human environments.

Conclusions:

  • Model organisms offer insights into potential aging and lifespan genetic mechanisms.
  • Significant uncertainties remain regarding the extent to which these mechanisms explain human lifespan variation.
  • Further research is needed to bridge the gap between model organism findings and human aging.