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Updated: Jul 8, 2026

Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
Published on: May 6, 2014
[Treatment of community-acquired pneumonia--treatment]
Ljubica Vukelic Andersen1, Birgitte Brock, Preben Jakobsen
1Arhus Universitetshospital, Arhus Sygehus, Klinisk Farmakologisk Afdeling, Arhus C. ljubica.andersen@farm.au.dk
Abstract:
Penicillin is the drug of choice for treatment of community-acquired pneumonia (CAP) in Denmark. The primary determinant for therapeutic activity of penicillin is ''penicillin time'' (T>MIC), i.e. time with penicillin concentration above minimum inhibitory concentration. Eradication of S. pneumoniae requires T>MIC above 40-50%. The second determinant for therapeutic activity is the ratio between maximum penicillin concentration in serum and MIC (Cmax/MIC). Considering penicillin pharmacokinetics, intravenous penicillin 2 million units four times a day is recommended as empirical treatment of CAP.
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