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Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
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Uveitis associated with multiple sclerosis

Julie Le Scanff1, Pascal Sève, Christel Renoux

  • 1Department of Internal Medicine, Hospices Civils de Lyon, Hotel Dieu, 1 place de l'Hôpital, 69288 Lyon Cedex 02, France.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|January 23, 2008
PubMed

Insights

This study found that uveitis occurs in 0.65% of multiple sclerosis (MS) patients. Uveitis timing relative to MS onset did not impact the disease

Area of Science:

  • Ophthalmology
  • Neurology
  • Immunology

Background:

  • Uveitis is an ocular inflammatory condition.
  • Multiple sclerosis (MS) is a chronic neurological disease.
  • The relationship between uveitis and MS requires further investigation.

Purpose of the Study:

  • To determine the prevalence of uveitis in multiple sclerosis patients.
  • To compare the clinical spectrum and time course of MS in patients with or without uveitis.

Main Methods:

  • Retrospective analysis of the Lyon MS Database.
  • Identification of patients diagnosed with uveitis.
  • Comparison of MS clinical course and prognosis between groups.

Main Results:

  • Prevalence of uveitis in the MS cohort was 0.65% (28/4,300).
  • Uveitis preceded MS onset in 46% of cases, occurred simultaneously in 18%, and followed in 36%.
  • No significant differences in MS course or prognosis were observed based on uveitis presence or timing.

Conclusions:

  • Uveitis is relatively uncommon in MS patients.
  • The timing of uveitis in relation to MS does not appear to affect MS prognosis.
  • Ocular inflammation in MS patients does not alter the neurological disease course.

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