Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dissolution kinetics of bezafibrate in two solid forms for oral administration.

R Cadorniga1, M T Hernanez, S Negro

  • 1Department of Pharmacy, Faculty of Pharmacy, University of Madrid, Spain.

European Journal of Drug Metabolism and Pharmacokinetics
|January 1, 1991
PubMed
Summary

This study compared the dissolution kinetics of two oral bezafibrate formulations, a conventional-release and a slow-release tablet. Significant differences in in vitro drug release behavior were observed between the two formulations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of Social Genetic Effects on Pigs Fed With Automatic Feeders Using a Visit-Based Approach.

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie·2025
Same author

Elevated mortality risks associated with late diagnosis of cancer in individuals with psychiatric disorders?

Journal of psychiatric research·2024
Same author

An agonist of CXCR4 induces a rapid recovery from the neurotoxic effects of Vipera ammodytes and Vipera aspis venoms.

Journal of neurochemistry·2023
Same author

Allele/haplotype variation in the MHC-DQA2 gene in Spanish sheep and its association with footrot susceptibility.

Research in veterinary science·2021
Same author

Demographic histories and genetic diversity across pinnipeds are shaped by human exploitation, ecology and life-history.

Nature communications·2018
Same author

Volunteering in hospitals to improve the quality of long stays in rehabilitation units.

Functional neurology·2018

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Pharmacokinetics

Background:

  • Bezafibrate is an oral medication used to manage lipid disorders.
  • Two solid oral formulations, conventional-release (A) and slow-release (C), are available in the Spanish market.
  • Understanding in vitro dissolution is crucial for predicting in vivo performance.

Purpose of the Study:

  • To investigate and compare the dissolution kinetics of two bezafibrate oral formulations.
  • To evaluate the in vitro drug release profiles of conventional and slow-release bezafibrate tablets.

Main Methods:

  • Dissolution studies were conducted using the United States Pharmacopeia (USP) XXI dissolution apparatus.
  • Drug solubility was determined in various release media at 37°C.

Related Experiment Videos

  • Dissolution rate-kinetics were analyzed using three distinct mathematical models.

    • Main Results:

    • Sink conditions were not met during the dissolution studies.
    • Significant differences in the in vitro dissolution behavior were observed between formulation A and formulation C.
    • The mathematical modeling revealed distinct kinetic profiles for each formulation.

    Conclusions:

    • The two bezafibrate formulations exhibit markedly different in vitro dissolution characteristics.
    • These findings highlight the importance of formulation design on drug release profiles.
    • Further in vivo studies may be warranted to correlate these in vitro differences with patient outcomes.