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Regression of Post-transplant Kaposi's sarcoma after Replacing Cyclosporine with Mycophenolate Mofetil

M M Hussein1, J M Mooij, H M Roujouleh

  • 1Department of Nephrology and Dialysis, Al Hada Armed Forces Hospital, Taif, Saudi Arabia.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|January 23, 2008
PubMed

Insights

This study shows that stopping cyclosporine and switching to mycophenolate mofetil (MMF) can help post-transplant Kaposi's sarcoma (KS) disappear. MMF maintained transplant function without hindering KS regression.

Area of Science:

  • Oncology
  • Immunology
  • Transplantation

Background:

  • Kaposi's sarcoma (KS) is linked to human herpes virus-8 (HHV-8).
  • Cyclosporine use is a known risk factor for post-transplant KS.
  • Limited data exists on newer immunosuppressants like mycophenolate mofetil (MMF) for KS treatment.

Purpose of the Study:

  • To report a case of post-transplant Kaposi's sarcoma (KS).
  • To evaluate the effect of switching from cyclosporine to mycophenolate mofetil (MMF) on KS regression and allograft function.

Main Methods:

  • A 52-year-old female patient developed KS post-living related transplantation.
  • Treatment involved replacing cyclosporine and azathioprine with MMF.
  • Allograft function and KS lesion status were monitored.

Main Results:

  • Kaposi's sarcoma lesions disappeared after initiating MMF.
  • Allograft function remained stable throughout the treatment period.
  • MMF facilitated KS regression without compromising graft survival.

Conclusions:

  • Discontinuation of cyclosporine is crucial for treating post-transplant KS.
  • Mycophenolate mofetil (MMF) is a viable alternative immunosuppressant that supports KS regression and maintains allograft function.

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