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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

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Acute renal failure in moroccan children.

Amal Bourquia¹, Fatima Chakib, Abdessadek Jennah

¹Al Amal, Centre de Néphrologie et Dialyse Pédiatriques, Casablanca, Morocco.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia

|January 23, 2008

Summary

This study on childhood acute renal failure (ARF) in Morocco found acute glomerulonephritis was the most common cause. Recovery was higher in non-oliguric patients, with favorable outcomes for most glomerular disease cases.

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Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Area of Science:

Pediatric Nephrology
Renal Medicine
Epidemiology

Background:

Acute renal failure (ARF) in children presents unique etiological and prognostic challenges.
Understanding the specific causes and outcomes of ARF in diverse populations is crucial for effective management.

Purpose of the Study:

To investigate the causes and prognosis of acute renal failure in Moroccan children.
To analyze treatment modalities, including dialysis, and their impact on outcomes.

Main Methods:

Retrospective analysis of 120 pediatric ARF cases from Casablanca, Morocco (1982-1999).
Data collection included patient demographics, causes of ARF, treatment received (dialysis type and indication), and patient outcomes.
Etiologies analyzed included acute glomerulonephritis, hemolytic uremic syndrome, renal hypoperfusion, and urinary tract obstruction.

Main Results:

The primary cause of ARF was acute glomerulonephritis (50.8%), followed by hemolytic uremic syndrome (15%).
74% of patients required dialysis, with hemodialysis being more common than peritoneal dialysis.
Mortality rate was 17%; recovery was more favorable in non-oliguric patients and those with glomerular disease (65% favorable outcome).

Conclusions:

Acute glomerulonephritis is the leading cause of ARF in Moroccan children.
While dialysis is frequently required, outcomes are generally favorable for glomerular disease, particularly in non-oliguric cases.
The study highlights the importance of identifying specific etiologies for improved pediatric ARF management.