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Updated: Aug 13, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Can a single androgen receptor fill the bill?

P J Sheridan1

  • 1Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.

Molecular and Cellular Endocrinology
|April 1, 1991
PubMed

Insights

The study suggests that a single androgen receptor is insufficient to explain the rapid effects of androgens. Additional nuclear and membrane receptors are likely involved in androgen signaling pathways.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Signaling

Background:

  • Androgens are crucial steroid hormones with diverse physiological effects.
  • The mechanisms underlying rapid androgen actions on target tissues are not fully understood.
  • Existing models propose androgen receptor (AR) involvement, but may not explain all observed phenomena.

Purpose of the Study:

  • To evaluate the necessity for additional nuclear and membrane receptors in mediating androgen effects.
  • To challenge the sufficiency of a single androgen receptor model for rapid androgen signaling.

Main Methods:

  • Hypothetical reasoning based on existing data and proposed hypotheses.
  • Analysis of rapid versus slow signaling pathways initiated by androgens.
  • Comparison of proposed receptor requirements with known androgen receptor functions.

Main Results:

  • The existence of two hypotheses necessitates at least one additional specific nuclear receptor for testosterone (T).
  • A membrane receptor is also required to explain the rapid effects of androgens on specific tissues.
  • A single androgen receptor cannot account for the full spectrum of androgen-induced responses.

Conclusions:

  • The current understanding of androgen action may require revision to include multiple receptors.
  • Specific nuclear and membrane receptors are likely critical for rapid androgen signaling.
  • Future research should focus on identifying and characterizing these additional androgen-binding proteins.

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