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Updated: Jul 8, 2026
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Full-intensity and reduced-intensity allogeneic stem cell transplantation in AML
1Centre for Clinical Haematology, University Hospital Birmingham NHS Trust, Birmingham, UK. charles.craddock@uhb.nhs.uk
Bone Marrow Transplantation
|January 23, 2008
Summary
Allogeneic stem cell transplantation is a key treatment for acute myeloid leukaemia (AML). Advances allow its use in more patients, including older adults, improving outcomes through graft-versus-leukaemia effects.
Area of Science:
- Hematology
- Oncology
- Transplant Immunology
Background:
- Allogeneic stem cell transplantation is a primary anti-leukaemic therapy for acute myeloid leukaemia (AML).
- Improvements in transplant technology and supportive care enhance outcomes for AML patients undergoing myeloablative conditioning.
Purpose of the Study:
- To review the role of allogeneic stem cell transplantation in acute myeloid leukaemia treatment.
- To highlight the expansion of transplantation eligibility to older patients and the utilization of alternative stem cell sources.
Main Methods:
- Review of current literature on allogeneic stem cell transplantation in AML.
- Analysis of conditioning regimens (myeloablative vs. reduced-intensity) and stem cell sources (unrelated, cord blood).
Main Results:
- Myeloablative conditioning with advances in supportive care has improved outcomes.
- Reduced-intensity conditioning enables exploitation of graft-versus-leukaemia effects in older/comorbid patients.
- Increased availability of unrelated and cord blood stem cells expands treatment options.
Conclusions:
- Allogeneic transplantation is a crucial therapeutic strategy for both younger and older adults with AML.
- The evolution of conditioning regimens and stem cell sources has broadened the applicability and success of this treatment.
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