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The folate binding proteins.

R Corrocher1, O Olivieri, M L Pacor

  • 1Istituto di Patologia Speciale Medica, Università di Verona, Italy.

Haematologica
|November 1, 1991
PubMed
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Folate binding proteins regulate the essential transport of folates into cells. This review covers current knowledge and recent advancements in understanding these crucial proteins.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Folates are vital for cellular functions, necessitating precise regulation of their transport.
  • Folate binding proteins (FBPs) are key regulators of folate uptake and bioavailability.
  • Understanding FBPs is crucial for comprehending cellular nutrient acquisition.

Purpose of the Study:

  • To review existing knowledge on folate binding proteins.
  • To highlight recent scientific advancements in the field of folate transport regulation.
  • To provide a comprehensive overview of FBP functions and significance.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of research on folate binding proteins.
  • Synthesis of current data on folate transport mechanisms.

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Main Results:

  • Folate binding proteins are central to the regulation of folate transport across biological membranes.
  • Recent studies have elucidated novel functions and structural insights into various FBPs.
  • The role of FBPs in both normal physiology and disease states is increasingly recognized.

Conclusions:

  • Folate binding proteins are indispensable for maintaining cellular folate homeostasis.
  • Continued research into FBPs promises to yield new therapeutic strategies for folate-related disorders.
  • This review consolidates current understanding and points towards future research directions for folate binding proteins.